Nanotechnology and cancer

The biological picture of cancer is rapidly advancing from models built from phenomenological descriptions to network models derived from systems biology, which can capture the evolving pathophysiology of the disease at the molecular level. The translation of this (still academic) picture into a clinically relevant framework can be enabling for the war on cancer, but it is a scientific and technological challenge. In this review, we discuss emerging in vitro diagnostic technologies and therapeutic approaches that are being developed to handle this challenge. Our discussion of in vitro diagnostics is guided by the theme of making large numbers of measurements accurately, sensitively, and at very low cost. We discuss diagnostic approaches based on microfluidics and nanotechnology. We then review the current state of the art of nanoparticle-based therapeutics that have reached the clinic. The goal of the presentation is to identify nanotherapeutic strategies that are designed to increase efficacy while simultaneously minimizing the toxic side effects commonly associated with cancer chemotherapies

Effect of particle size of Martian dust on the degradation of photovoltaic cell performance

Glass coverglass and SiO2 covered and uncovered silicon photovoltaic (PV) cells were subjected to conditions simulating a Mars dust storm, using the Martian Surface Wind Tunnel, to assess the effect of particle size on the performance of PV cells in the Martian environment. The dust used was an artificial mineral of the approximate elemental composition of Martian soil, which was sorted into four different size ranges. Samples were tested both initially clean and initially dusted. The samples were exposed to clear and dust laden winds, wind velocities varying from 23 to 116 m/s, and attack angles from 0 to 90 deg. It was found that transmittance through the coverglass approximates the power produced by a dusty PV cell. Occultation by the dust was found to dominate the performance degradation for wind velocities below 50 m/s, whereas abrasion dominates the degradation at wind velocities above 85 m/s. Occultation is most severe at 0 deg (parallel to the wind), is less pronounced from 22.5 to 67.5 deg, and is somewhat larger at 90 deg (perpendicular to the wind). Abrasion is negligible at 0 deg, and increases to a maximum at 90 deg. Occultation is more of a problem with small particles, whereas large particles (unless they are agglomerates) cause more abrasion

The chemical effects of the Martian environment on power system component materials: A theoretical approach

In the foreseeable future, an expedition may be undertaken to explore the planet Mars. Some of the power source options being considered for such a mission are photovoltaics, regenerative fuel cells and nuclear reactors. In addition to electrical power requirements, environmental conditions en route to Mars, in the planetary orbit and on the Martian surface must be simulated and studied in order to anticipate and solve potential problems. Space power systems components such as photovoltaic arrays, radiators, and solar concentrators may be vulnerable to degradation in the Martian environment. Natural characteristics of Mars which may pose a threat to surface power systems include high velocity winds, dust, ultraviolet radiation, large daily variation in temperature, reaction to components of the soil, atmosphere and atmospheric condensates as well as synergistic combinations. Most of the current knowledge of the characteristics of the Martian atmosphere and soil composition was obtained from the Viking 1 and 2 missions in 1976. A theoretical study is presented which was used to assess the effects of the Martian atmospheric conditions on the power systems components. A computer program written at NASA-Lewis for combustion research that uses a free energy minimization technique was used to calculate chemical equilibrium for assigned thermodynamic states of temperature and pressure. The power system component materials selected for this study include: silicon dioxide, silicon, carbon, copper, and titanium. Combinations of environments and materials considered include: (1) Mars atmosphere with power surface material, (2) Mars atmosphere and dust component with power surface material, and (3) Mars atmosphere and hydrogen peroxide or superoxide or superoxide with power system material. The chemical equilibrium calculations were performed at a composition ratio (oxidant to reactant) of 100. The temperature for the silicon dioxide material and silicon, which simulate photovoltaic cells, were 300 and 400 K; for carbon, copper and titanium, which simulate radiator surfaces, 300, 500, and 1000 K. All of the systems were evaluated at pressures of 700, 800, and 900 Pa, which stimulate the Martian atmosphere

Aeolian Removal of Dust Types from Photovoltaic Surfaces on Mars

Dust elevated in local or global dust storms on the Martian surface could settle on photovoltaic (PV) surfaces and seriously hamper their performance. Using a recently developed technique to apply a uniform dust layer, PV surface materials were subjected to simulated Martian winds in an attempt to determine whether natural aeolian processes on Mars would sweep off the settled dust. Three different types of dust were used. The effects of wind velocity, angle of attack, height above the Martian surface, and surface coating material were investigated. It was found that arrays mounted on an angle of attack approaching 45 deg show the most efficient clearing. Although the angular dependence is not sharp, horizontally mounted arrays required much higher wind velocities to clear off the dust. From this test it appears that the arrays may be erected quite near the ground, but previous studies have suggested that saltation effects can be expected to cause such arrays to be covered by soil if they are set up less than about a meter from the ground. Particle size effect appear to dominate over surface chemistry in these experiments, but additional tests are required to confirm this

Combination of geodetic observations and models for glacial isostatic adjustment fields in Fennoscandia

We demonstrate a new technique for using geodetic data to update a priori predictions for Glacial Isostatic Adjustment (GIA) in the Fennoscandia region. Global Positioning System (GPS), tide gauge, and Gravity Recovery and Climate Experiment (GRACE) gravity rates are assimilated into our model. The technique allows us to investigate the individual contributions from these data sets to the output GIA model in a self-consistent manner. Another benefit of the technique is that we are able to estimate uncertainties for the output model. These are reduced with each data set assimilated. Any uncertainties in the GPS reference frame are absorbed by reference frame adjustments that are estimated as part of the assimilation. Our updated model shows a spatial pattern and magnitude of peak uplift that is consistent with previous models, but our location of peak uplift is slightly to the east of many of these. We also simultaneously estimate a spatially averaged rate of local sea level rise. This regional rate (similar to 1.5 mm/yr) is consistent for all solutions, regardless of which data sets are assimilated or the magnitude of a priori GPS reference frame constraints. However, this is only the case if a uniform regional gravity rate, probably representing errors in, or unmodeled contributions to, the low-degree harmonic terms from GRACE, is also estimated for the assimilated GRACE data. Our estimated sea level rate is consistent with estimates obtained using a more traditional approach of direct "correction" using collocated GPS and tide gauge site

Sensible heat receiver for solar dynamic space power system

A sensible heat receiver considered in this study uses a vapor grown carbon fiber-carbon (VGCF/C) composite as the thermal storage media and was designed for a 7 kW Brayton engine. The proposed heat receiver stores the required energy to power the system during eclipse in the VGCF/C composite. The heat receiver thermal analysis was conducted through the Systems Improved Numerical Differencing Analyzer and Fluid Integrator (SINDA) software package. The sensible heat receiver compares well with other latent and advanced sensible heat receivers analyzed in other studies while avoiding the problems associated with latent heat storage salts and liquid metal heat pipes. The concept also satisfies the design requirements for a 7 kW Brayton engine system. The weight and size of the system can be optimized by changes in geometry and technology advances for this new material

Feeder Cattle Basis in South Carolina 2000-2004

Livestock Production/Industries,

Aeolian removal of dust from photovoltaic surfaces on Mars

It is well documented that Mars is totally engulfed in huge dust storms nearly each Martian year. Dust elevated in these global dust storms, or in any of the numerous local dust storms could settle on photovoltaic surfaces and seriously hamper photovoltaic power system performance. Using a recently developed technique to uniformly dust simulated photovoltaic surfaces, samples were subjected to Martian-like winds in an attempt to determine whether natural aeolian processes on Mars would sweep off the settled dust. The effects of wind velocity, angle of attack, height off the Martian surface, and surface coating material were investigated. Principles which can help to guide the design of photovoltaic arrays bound for the Martian surface were uncovered. Most importantly, arrays mounted with an angle of attack approaching 45 deg show the most efficient clearing. Although the angular dependence is not sharp, horizontally mounted arrays required significantly higher wind velocities to clear off the dust. From the perspective of dust-clearing it appears that the arrays may be erected quite near the ground, but previous studies have suggested that saltation effects can be expected to cause such arrays to be covered by sand if they are set up less than about a meter from the ground. Providing that the surface chemistry of Martian dusts is comparable to our test dust, the materials used for protective coating may be optimized for other considerations such as transparency, and chemical or abrasion resistance. The static threshold velocity is low enough that there are regions on Mars which experience winds strong enough to clear off a photovoltaic array if it is properly oriented. Turbulence fences proved to be an ineffective strategy to keep dust cleared from the photovoltaic surfaces

Phoretic and Radiometric Force Measurements on Microparticles in Microgravity Conditions

Thermophoretic, diffusiophoretic and radiometric forces on microparticles are being measured over a wide range of gas phase and particle conditions using electrodynamic levitation of single particles to simulate microgravity conditions. The thermophoretic force, which arises when a particle exists in a gas having a temperature gradient, is measured by levitating an electrically charged particle between heated and cooled plates mounted in a vacuum chamber. The diffusiophoretic force arising from a concentration gradient in the gas phase is measured in a similar manner except that the heat exchangers are coated with liquids to establish a vapor concentration gradient. These phoretic forces and the radiation pressure force acting on a particle are measured directly in terms of the change in the dc field required to levitate the particle with and without the force applied. The apparatus developed for the research and the experimental techniques are discussed, and results obtained by thermophoresis experiments are presented. The determination of the momentum and energy accommodation coefficients associated with molecular collisions between gases molecules and particles and the measurement of the interaction between electromagnetic radiation and small particles are of particular interest